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目的采用中心组合设计法优化超临界CO2技术提取大黄蒽醌的工艺。方法以提取温度、提取压力、夹带剂流速为自变量,大黄蒽醌提取率、纯度和提取总量为因变量,通过对自变量各水平的多元线性回归及二项式拟合,用效应面图和重叠等高线图选取较佳工艺,并进行验证分析。结果确定超临界CO2提取大黄蒽醌最优工艺为超临界提取温度39.7℃、提取压力42.9MPa、夹带剂流速3.14mL·min-1或提取温度50.3℃、提取压力42.9MPa、夹带剂流速2.15mL·min-1。结论中心组合设计法能够优选超临界CO2提取大黄蒽醌的工艺,方法简便,参数设置精度更高。
Objective To optimize the process of extraction of rhubarb from supercritical CO2 using the central composite design method. Methods The extraction temperature, extraction pressure, and entrainer flow rate were taken as independent variables. The extraction rate, purity, and total amount of extracts of rhubarb were used as dependent variables. Multiple linear regressions and binomial fits were applied to each level of the independent variables to use the effect surface. Maps and overlapping contour plots select the best process and perform validation analysis. Results The optimum conditions for extraction of rhubarb from supercritical CO2 were as follows: supercritical extraction temperature 39.7°C, extraction pressure 42.9 MPa, entrainer flow rate 3.14 mL·min-1 or extraction temperature 50.3°C, extraction pressure 42.9 MPa, entrainer flow rate 2.15 mL ·min-1. Conclusion The center combination design method can optimize the process of extracting rhubarb from supercritical CO2. The method is simple and the parameter setting precision is higher.