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目的:分析呼吸道感染患儿肺炎链球菌耐药情况,为临床合理使用抗菌药物提供依据。方法:对我院2 235例下呼吸道感染患儿的痰标本进行细菌培养鉴定,分离肺炎链球菌并进行药敏试验,分析患儿肺炎链球菌耐药性。结果:2 235例下呼吸道感染患儿的痰标本共检出肺炎链球菌200株,检出率为8.95%,占分离病原菌的27.93%。年龄1岁以内和冬季患儿的肺炎链球菌检出率分别为11.17%、10.76%,显著高于其他组的检出率;肺炎链球菌对阿莫西林、头孢曲松、氧氟沙星、万古霉素的敏感性高(>94.5%);对青霉素、头孢呋辛、红霉素的耐药性呈逐年上升趋势。结论:对小儿下呼吸道的肺炎链球菌感染治疗时,应注意合理选用抗菌药物,从而减少细菌耐药性的产生。
OBJECTIVE: To analyze the drug resistance of Streptococcus pneumoniae in children with respiratory tract infection, and to provide basis for the rational use of antibacterials in clinic. Methods: Sputum samples from 2 235 children with lower respiratory tract infection in our hospital were identified by bacterial culture. Streptococcus pneumoniae was isolated and drug susceptibility test was performed to analyze the drug resistance of Streptococcus pneumoniae in children. Results: Two hundred and seventy two cases of children with lower respiratory tract infection were detected in sputum samples of 200 strains of Streptococcus pneumoniae, the detection rate was 8.95%, accounting for 27.93% of isolated pathogens. The detection rate of S. pneumoniae was 11.17% and 10.76% respectively in children under 1 year of age and in winter, which was significantly higher than that of other groups. The detection rate of S. pneumoniae to amoxicillin, ceftriaxone, ofloxacin, The sensitivity of vancomycin was high (> 94.5%). The resistance to penicillin, cefuroxime and erythromycin showed an upward trend year by year. Conclusion: In the treatment of children with lower respiratory tract infection of Streptococcus pneumoniae, we should pay attention to the rational use of antimicrobial agents to reduce the bacterial resistance.