【摘 要】
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Dear Editor,Propofol (2,6-diisopropylphenol) has been widely used in clinical surgery because of its fast induction and rapid recovery effects (Miller et al.,20
【机 构】
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State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Lif
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Dear Editor,Propofol (2,6-diisopropylphenol) has been widely used in clinical surgery because of its fast induction and rapid recovery effects (Miller et al.,2014).Although the underlying mechanisms are still controversial,many studies have focused on the augmentation of GABA-induced inhibition and/or modulation of glycine receptor channel activity.However,inhibition of glutamatergic synaptic transmission may also contribute to general anesthesia.The effects of general anesthetics are significantly enhanced when glutamate receptor antagonists are co-administered (Ishizaki et al.,1996).Intrathecal administration of both GABAA and glycine receptor antagonist only increase the minimum alveolar concentration ～50％,suggesting that enhanced inhibitory synaptic transmission is not sufficient to account for general anesthesia (Zhang et al.,2001).However,the underlying mechanisms by which intravenous anesthetics inhibit glutamatergic synaptic transmission remain unclear.
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