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经口分别给予Wistar大鼠蒸馏水、DMF 400mg/kg、乙醇1000mg/kg及DMF400mg/kg+乙醇1000mg/kg,染毒21天。结果表明DMF组及联合染毒组大鼠血清ALT明显增高,SLDH在后者也明显升高,且两组肝组织ATP酶及SDH活性明显降低。各染毒组尿LDH活性显著上升,DMF组及联合染毒r-GT活性显著降低,此两组肾脏组织AKP、ATP、SDH活性也明显降低。上述变化联合染毒组较单独作用组明显,因此认为DMF对肝肾具有损伤作用,乙醇可加重DMF的损伤作用。
Oral Wistar rats were given distilled water, DMF 400mg / kg, ethanol 1000mg / kg and DMF400mg / kg + ethanol 1000mg / kg, for 21 days. The results showed that serum ALT levels were significantly increased in DMF group and the combined exposure group, SLDH in the latter was also significantly increased, and activity of ATPase and SDH in liver tissue of the two groups was significantly decreased. Urine LDH activity increased significantly in each exposure group, and activity of r-GT in DMF group and combination exposure group decreased significantly. Activity of AKP, ATP, SDH in both groups also decreased significantly. The combination of the above changes were significantly more than the separate group, that DMF on liver and kidney injury, ethanol can aggravate the injury of DMF.