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采用四氯化碳灌胃方法制成豚鼠肝硬变模型。通过观察豚鼠胆囊结石形成．扫描电镜观察胆石细微结构，并结合豚鼠肝脏及胆囊超微结构变化及胆囊胆汁结合胆汁酸簿层色谱扫描定量测定，以探讨肝硬变状态下胆石发生机理。结果显示各组动物胆石发生率：对照组5％，慢性肝损害组37．5％，肝硬变组83．3％。胆囊胆汁中结合胆汁酸：慢性肝损害组及肝硬变组均明显低于对照组，以肝硬变组下降最为明显。结果表明：肝硬变状态下结合胆汁酸含量下降，胆石发生率明显增高。
Guinea pig cirrhosis models were made by intragastric administration of carbon tetrachloride. Through the observation of guinea pig gallstone formation. Scanning electron microscopy was used to observe the glabrous structure of gallstone, and combined with changes of ultrastructure of gallbladder and gallbladder in gallbladder, and quantitative analysis of gallbladder combined with bile acid by chromatographic scanning to explore the mechanism of gallstone in cirrhosis. The results showed that the incidence of gallstone in each group was 5% in the control group, 37.5% in the chronic liver injury group and 83.3% in the cirrhosis group. Gallbladder bile combined with bile acids: chronic liver injury group and cirrhosis group were significantly lower than the control group, the most obvious decline in cirrhosis group. The results showed that: the state of cirrhosis with decreased bile acid content, the incidence of gallstone was significantly increased.