目的 为了解流行性感冒（流感）疫苗免疫效果及安全性。方法　1999年1～2月在杭州市192名7～9岁儿童进行了疫苗接种前后免疫水平观察。结果 甲1型（H2N2）、甲3型（H3N2）和乙型流感HI抗体阳性保护率分别由1.56％、53.13％、52.60％上升到82.81％,87.50％和97.92％;平均抗体增长幅度分别是免疫前的18.9,2.9和5.69倍。副反应发生率为1.6％。结论 证实流感疫苗具有良好的免疫效果和安全性,值得进一步推广应用。 Objective To understand the immunization effect and safety of influenza (influenza) vaccine. Methods From January to February 1999, 192 children aged 7 to 9 years old in Hangzhou were investigated before and after vaccination. Results The positive rates of H2N2, H3N2 and HI were increased from 1.56%, 53.13% and 52.60% to 82.81%, 87.50% and 97.92%, respectively. The average antibody growth rates were 18.9, 2.9 and 5.69 times before immunization. The incidence of side effects was 1.6%. Conclusion confirmed that the flu vaccine has good immune effect and safety, it is worth further promotion and application.