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自1929年发现青霉素并于40年代用于临床以来的半个多世纪,用抗生素治疗人类感染性疾病,保障人类健康方面取得了令人瞩目的辉煌成就,抗生素已成为当今不可缺少的一类重要化学药品。随着抗生素研究的不断深入,作用对象的不断扩大,人们在“抗菌”抗生素之外又找到抗肿瘤、抗原虫、抗寄生虫等用于人、畜及农业的抗生素。60年代后期,Umezawa等用新抗生素筛选相似的程序,以人体代谢过程中的特殊酶为靶子,筛选微生物产生的低分子酶抑制剂。日本学者十分重视从微生物代谢产物中筛选分离具有某种生理活性的物质。由他们编辑出版的国际性抗生素杂志《Journal of Antibiotics》于70年代初即增加了
For more than half a century since the discovery of penicillin in 1929 and its clinical use in the 1940s, remarkable achievements have been made in antibiotics to treat human infectious diseases and human health, and antibiotics have become an indispensable and important category today chemical. With the deepening of the research on antibiotics and the expansion of the role of the object, people find anti-tumor, anti-protozoan and anti-parasitic antibiotics for human, livestock and agriculture in addition to the antibacterial antibiotics. In the late 1960s, Umezawa et al. Screened a similar procedure with a new antibiotic to target specific enzymes in human metabolism to screen for low molecular enzyme inhibitors produced by microorganisms. Japanese scholars attach great importance to the screening of microorganisms metabolites have a certain physiological activity of substances. The international antibiotic magazine “Journal of Antibiotics” edited and published by them increased in the early 1970s