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目的:探讨血清降钙素原(PCT)在诊断早期急性胰腺炎合并感染中的临床价值。方法:选择96例急性胰腺炎患者,按其病情程度分为轻症急性胰腺炎(MAP)组50例、重症急性胰腺炎(SAP)组46例,分别于入院第1天、第3天、第5天、第7天对其血清PCT水平进行检测,并与正常对照组40例健康受试者进行比较分析,同时将三组血清降钙素原阳性率及急性胰腺炎患者住院第7天与第1天的阳性率比较。结果:SAP组及MAP组入院第1天的血清降钙素原水平及阳性率显著高于对照组(P<0.05),且SAP组入院第1、3、5、7天的血清降钙素原水平及阳性率显著高于MAP组(P<0.05),且96例急性胰腺炎患者的住院第7天的阳性率显著低于住院第1天的阳性率(P<0.05)。结论:监测急性胰腺炎患者血清PCT水平变化,对疾病的早期诊断、病情判断和预后评估均具有重要的临床意义。
Objective: To investigate the clinical value of serum procalcitonin (PCT) in the diagnosis of early-stage acute pancreatitis complicated with infection. Methods: Ninety-six patients with acute pancreatitis were divided into 50 cases of mild acute pancreatitis (MAP) and 46 cases of severe acute pancreatitis (SAP) On the 5th and 7th day, the level of serum PCT was detected and compared with the normal control group of 40 healthy subjects, and the three groups of patients with positive serum procalcitonin and acute pancreatitis were hospitalized on the 7th day Compared with the first day of positive rate. Results: The levels of serum procalcitonin and the positive rate of SAP on the first day after admission in SAP group and MAP group were significantly higher than those in control group (P <0.05), and the serum calcitonin (P <0.05). The positive rate of hospitalization on day 7 in 96 patients with acute pancreatitis was significantly lower than that on day 1 of hospitalization (P <0.05). Conclusion: The changes of serum PCT levels in patients with acute pancreatitis have important clinical significance in early diagnosis, assessment of disease and prognosis.