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【目的】探讨环氧合酶-2(COX-2)蛋白在喉癌中的表达及其临床意义,同时探讨其在喉乳头状瘤和声带息肉中的表达情况。【方法】采用免疫组化SP法检测38例喉鳞癌、7例喉乳头状瘤及10例声带息肉组织中COX-2蛋白的表达水平。【结果】COX-2蛋白在喉癌中的表达水平明显高于声带息肉(P<0.01);喉乳头状瘤中的表达明显高于声带息肉(P<0.01);声带息肉中几乎未见COX-2表达。在喉癌组的组织分级中,COX-2蛋白在高分化组织中的表达明显高于中度分化(P<0.01)和低分化(P<0.01);在中度分化组织中的表达明显高于低分化(P<0.01);COX-2蛋白在各临床分期、T分级、N分级、肿瘤部位及年龄中差异均无显著性(P>0.05)。【结论】①COX-2蛋白与喉鳞状细胞癌的组织学分化程度密切相关;②COX-2蛋白在小儿喉乳头状瘤复发和成人乳头状瘤发生方面可能起到一定的作用。
【Objective】 To investigate the expression of cyclooxygenase-2 (COX-2) protein in laryngeal carcinoma and its clinical significance, and to investigate its expression in laryngeal papilloma and vocal cord polyp. 【Methods】 The immunohistochemical SP method was used to detect the expression of COX-2 protein in 38 cases of laryngeal squamous cell carcinoma, 7 cases of laryngeal papilloma and 10 cases of vocal cord polyps. [Results] The expression of COX-2 protein in laryngeal carcinoma was significantly higher than that in vocal cord polyps (P <0.01), and the expression in laryngeal papilloma was significantly higher than that in vocal cord polyp (P <0.01). There was almost no COX -2 expression. The expression of COX-2 protein in well-differentiated tissues was significantly higher than that in moderately differentiated tissues (P <0.01) and poorly differentiated tissues (P <0.01), while it was significantly higher in moderately differentiated tissues (P <0.01). There was no significant difference in clinical stage, T grade, N grade, tumor location and age among COX-2 protein (P> 0.05). 【Conclusion】 ①COX-2 protein is closely related to histological differentiation of laryngeal squamous cell carcinoma; ②COX-2 protein may play a role in the relapse of pediatric laryngeal papilloma and adult papilloma.