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喉癌的男性发病率较高,是因为男性血浆中的雄激素较女性为高之故。男女性的喉部都是雄激素类固醇的靶标,男性青春期睾丸雄激素促成正常的变音,女性使用雄激素制剂以后也能引起变音。性类固醇对于喉组织细胞的作用,是由细胞浆内的类固醇受体所调节,故设想雄激素受体能影响喉癌的生长、分化及其形态学变化。喉癌如果含有这种受体,对于“抗雄激素疗法”(现已证明对于多种类固醇所致的癌瘤都有疗效)必然敏感。这一疗法对于雄激素所致的喉癌,特别是不能进行手术和放疗的晚期病例应该有效。本文目的在于确定正常喉组织和恶性喉组织的雄激素。喉癌组织取自18例男性病人(51～75岁)的
Male patients with laryngeal cancer incidence is higher, because male androgen in plasma is higher than women. Both male and female throats are targets of androgen steroids. Male adolescent testosterone androgen lead to normal diathesis, and women can also cause diathesis after androgen use. The effect of sex steroids on laryngeal tissue cells is regulated by steroid receptors in the cytoplasm. Therefore, it is hypothesized that androgen receptors can affect the growth, differentiation and morphological changes of laryngeal cancer. Laryngeal cancer, if it contains this receptor, must be sensitive to “anti-androgen therapy,” which has been shown to work well for many steroid-induced carcinomas. This treatment should be effective for androgen-induced laryngeal cancer, especially in advanced cases that can not undergo surgery and radiotherapy. The purpose of this article is to determine androgen in normal and malignant laryngeal tissues. Laryngeal cancer tissue taken from 18 cases of male patients (51 to 75 years old)