论文部分内容阅读
Bowman-Birk蛋白酶抑制剂(BBI)是一种植物丝氨酸蛋白酶抑制剂,能同时抑制胰蛋白酶和胰凝乳蛋白酶。体外及动物实验都证实:BBI纯品或BBI浓缩物均有较强的抗癌活性。本文综述了近年来有关BBI的一些抗癌研究进展,包括BBI的结构、临床前研究及可能的分子机制等。
Bowman-Birk Protease Inhibitor (BBI) is a plant serine protease inhibitor that inhibits both trypsin and chymotrypsin. In vitro and animal experiments have confirmed: BBI pure or BBI concentrate have strong anti-cancer activity. This review summarizes some advances in anti-cancer research on BBI in recent years, including the structure of BBI, preclinical studies and possible molecular mechanisms.