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将杂色豚鼠45只随机分为对照组(15只)和实验组(30只),全部豚鼠每天肌注卡那霉素400mg/kg,连续10天;实验组同时口服甲状腺素,隔日10mg/kg,连续5次。适时测定PR和ABR,并在用药后第20天断头处死豚鼠,取出耳蜗制片观察。结果表明,实验组PR和ABR的出现率显著高于对照组,ABR阈值显著低于对照组,PR阈值首先表现为高频区的阈值低于对照组;耳蜗各回听毛细胞的静纤毛缺损及变性实验组均轻于对照组。提示甲状腺素可减轻卡那霉素对耳蜗的毒性。
Forty-five guinea pigs were randomly divided into control group (n = 15) and experimental group (n = 30). All guinea pigs were intramuscularly injected with kanamycin 400mg / kg for 10 consecutive days. kg, 5 times in a row. Timely determination of PR and ABR, and guinea pigs were decapitated 20 days after the administration, remove the cochlear production observations. The results showed that the incidence of PR and ABR in the experimental group was significantly higher than that in the control group, and the ABR threshold was significantly lower than that in the control group. The PR threshold first showed that the threshold of the high frequency region was lower than that of the control group. Denaturation experimental group were lighter than the control group. Tip thyroxine can reduce the toxicity of kanamycin on the cochlea.