The spaceplane is perspective vehicle due to wide maneuverability in comparison with a space capsule. Its maneuverability is expressed by the larger flight range and also by a possibility to rotate orbital inclination in the atmosphere by the aerodynamic and thrust forces. Orbital plane atmospheric rotation maneuvers can significantly reduce fuel costs compared to rocket-dynamic non-coplanar maneuver. However, this maneuver occurs at Mach numbers about 25, and such velocities lead to non-equilibrium chemical reactions in the shock wave. Such reactions change a physicochemical air property, and it affects aerodynamic coefficients. This paper investigates the influence of non-equilibrium reactions on the aerothrust aeroassisted maneuver with orbital change. The approach is to solve an optimization problem using the differential evolution algorithm with a temperature limitation. The spaceplane aerodynamic coefficients are determined by the numerical solution of the Reynolds-averaged Navier-Stokes equations. The aerodynamic calculations are con-ducted for the cases of perfect and non-equilibrium gases. A comparison of optimal trajectories, control laws, and fuel costs is made between models of perfect and non-equilibrium gases. The effect of a chemically reacting gas on the finite parameters is also evaluated using control laws obtained for a perfect gas.