目的　研究子宫肌瘤患者子宫平滑肌组织及肌瘤组织中血管内皮生长因子 (VEGF)及胰岛素样生长因子Ⅰ受体 (IGF IR)的表达 ,探讨子宫肌瘤的发病机制。方法　采用免疫组化SP法检测 30例子宫肌瘤患者的平滑肌组织和肌瘤组织中VEGF和IGF IR的表达。结果　VEGF在子宫平滑肌组织及肌瘤组织中均有表达 ,但差异无显著意义。IGF IR在子宫平滑肌组织及肌瘤组织中均有表达 ,且肌瘤内的表达明显高于肌层 (P <0 .0 5 )。结论　VEGF在子宫肌瘤的发病过程中作用不大 ,可能充当促血管生长因子 ,为肌瘤提供血供 ,IGF IR表达增高 ,与肌瘤的发病有关 Objective To study the expression of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 receptor (IGF-IR) in uterine fibroids and uterine fibroids and to explore the pathogenesis of uterine fibroids. Methods Immunohistochemical SP method was used to detect the expression of VEGF and IGF IR in 30 cases of myoma of uterine fibroids. Results VEGF was expressed in both uterine smooth muscle and fibroid tissue, but the difference was not significant. IGF IR was expressed in both uterine smooth muscle and fibroid tissue, and the expression of IGF IR in myoma was significantly higher than that in muscle (P <0.05). Conclusions VEGF plays a minor role in the pathogenesis of uterine fibroids and may serve as a pro-angiogenic factor that supplies blood supply to fibroids with an increased expression of IGF-IR, which is associated with the onset of fibroids