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观察5-氨基酮戊酸光动力疗法(ALA-PDT)三阶段治疗鲍温样丘疹病的疗效和安全性。方法回顾性分析我科诊治的82例鲍温样丘疹病患者,分为单纯CO_2激光组21例、CO_2激光联合咪喹莫特治疗组30例、光动力三阶段治疗组31例。结果 CO_2激光组患者有效率为52.38%(11/21),复发率57.14%(12/21);CO_2激光联合咪喹莫特治疗组有效率为80%(24/30),复发率26.67%(8/30);ALA-PDT三阶段治疗组患者的有效率为83.87%(26/31),复发率为3.23%(1/31)。三组患者有效率及复发率比较差异均有统计学意义(P<0.05)。结论 CO_2联合咪喹莫特及光动力疗法治疗鲍温样丘疹病,可以显著提高有效率,减少复发,不良反应发生率低,值得临床推广。
To observe the efficacy and safety of three-stage ALA-PDT in the treatment of Bowenoid papulosis. Methods A retrospective analysis of 82 cases of Bowen-like papulosis in our department was divided into 21 cases of CO 2 laser group, 30 cases of CO 2 laser combined with imiquimod treatment group and 31 cases of three-phase photodynamic therapy group. Results The effective rate was 52.38% (11/21) in CO 2 laser group and 57.14% (12/21) in CO 2 laser group. The effective rate was 80% (24/30) in CO 2 laser combined with imiquimod, and the recurrence rate was 26.67% (8/30). The effective rate of ALT-PDT in the three-stage treatment group was 83.87% (26/31) and the recurrence rate was 3.23% (1/31). Three groups of patients with effective rate and recurrence rate differences were statistically significant (P <0.05). Conclusion CO 2 combined with imiquimod and photodynamic therapy for Bowenoid papulosis can significantly improve the efficiency and reduce recurrence, the incidence of adverse reactions is low, worthy of clinical promotion.