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观察抗肝癌iRNA及S－TF对原发性肝癌（PHC）患者外周血LAK、IL－2活性及IL－2R表达的影响。发现PHC病人LAK、IL－2活性及IL－2R表达均明显低于正常人，且IL-2与LAK间呈正相关；经抗肝癌iRNA及S-TF治疗后，PHC病人的上述指标及WBC数均较治疗前显著升高。提示PHC病人的免疫功能低下或紊乱可能与肿瘤的发生及发展有关，应用抗肝癌iRNA及S－TF可给肿瘤宿主转移介导其细胞免疫功能，改善其免疫状态。
The effects of anti-hepatoma iRNA and S-TF on the activity of LAK, IL-2 and the expression of IL-2R in peripheral blood of patients with primary liver cancer (PHC) were observed. The activity of LAK, IL-2 and the expression of IL-2R in PHC patients were significantly lower than those in normal subjects, and there was a positive correlation between IL-2 and LAK; the above indicators and WBC counts in PHC patients after treatment with anti-hepatoma iRNA and S-TF. Significantly higher than before treatment. It is suggested that the immunologic dysfunction or disorder in PHC patients may be related to the occurrence and development of tumors. The application of anti-hepatocarcinoma iRNA and S-TF may transfer the cellular immune function to tumor hosts and improve their immune status.