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目的探讨抗纤方阻断肝纤维化的作用机理．力法用ＣＣｌ_４造模后灌服药物，对照观察抗纤方与秋水仙碱。大黄■虫丸组等的不同作用结果各组谷雨转氨酶均较空模组为低（ Ｐ ＜ ０． ０１），，而血清蛋白较空模组副 （Ｐ ＜ ０． ０１）抗纤方大、中剂量组 ＨｙＰ含量较空模组低（Ｐ ＜ ０． ０５）；光镜显示：抗纤方组肝内纤维组织增生和肝细胞变性坏死程度明显减轻；电镜结果显示：抗纤方组胶原纤维生成较少结论抗纤方能促进肝细胞修复、恢复肝脏正常功能、改善微循环、促进胶原纤维降解，以达到抗肝纤维化的作用
1. Objective To explore the mechanism of antifibrotic agents blocking liver fibrosis. The force method was used to irrigate the drugs after the model was established with CCl_4, and the anti-fibrosis and colchicine were observed. The results of different effects of rhubarb-Zhongwan Pills were lower in all groups than those in the empty model group (P < 0. 01), while serum albumin was larger than the empty module group (P < 0. 01). The level of HyP in the middle dose group was lower than that in the blank group (P < 0.05). Light microscopy showed that the hepatic fibrous tissue proliferation and hepatocyte degeneration and necrosis were significantly reduced in the anti-fibrosis group; the results of electron microscopy showed that the anti-fibrosis group collagen fibers Produce less conclusions Anti-fibrosine can promote liver cell repair, restore normal liver function, improve microcirculation, promote collagen fiber degradation, and achieve anti-fibrosis effect