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Objective To find out a specific method for diagnosis of malignant pleural effusions (MPEs)with higher sensitivity and practicality. Methods The diagnosis of MPEs were made using density gradient cen-trifugation(DGC) , smear cytologic examination( SCE) and pleural needle biopsy (PNB). Comparisons between these results and those of benign pleural effusions were also made. Results The positive rates of DGC,SCE and PNB for diagnosing MPEs were 94. 3% ,62. 9% and 44. 6% , respectively, and the positive rate of SCE combined with PNB for diagnosing MPEs was 73. 2%. The positive rate of the exfoliative tumor cells ( ETCs ) by DGC was much higher than that of SCE or/and PNB with no false-positive. Conclusion The ETCs isolated by DGC from the MPEs is quite specific for the diagnosis of malignant tumors with higher sensitivity and practicality in clinico-patho-logical practice.
Methods The diagnosis of MPEs were made using density gradient cen-trifugation (DGC), smear cytologic examination (SCE) and pleural needle biopsy (MPEs) with higher sensitivity and practicality. PNB). Comparisons between these results and those of benign pleural effusions were also made. Results The positive rates of DGC, SCE and PNB for diagnosing MPEs were 94.3%, 62.9% and 44. 6% respectively, respectively The positive rate of the exfoliative tumor cells (ETCs) by DGC was much higher than that of SCE or / and PNB with no false-positive. Conclusion The ETCs isolated by DGC from the MPEs is quite specific for the diagnosis of malignant tumors with higher sensitivity and practicality in clinico-patho-logical practice.