Ｈｏｌｔ Ｏｒａｍ综合征又称心 手综合征 ,国内文献未见报道。由于本综合征罕见 ,临床上容易漏诊。本院儿科近 2 0年来先后收治 2例 ,报告如下。例 1:女性 ,2 2天 ,Ｇ2 Ｐ1,足月顺产 ,因发热 4ｄ入院 ,家族中无类似患者。体检呈现特殊面容 ,两眼距增宽 ,鼻根部低平 ,下颌骨较 Holt Oram syndrome, also known as heart syndrome, domestic literature has not been reported. As the rare syndrome, clinically easy to miss. The hospital pediatric nearly 20 years has admitted to 2 cases, the report is as follows. Example 1: Female, 2 days, G2 P1, full term, spontaneous 4 days admitted to hospital, no similar family members. Physical examination showed a special face, widening eyes, nasal flat low, mandibular