脂质代谢紊乱是动脉粥样硬化的主要危险因素,研究发现氧化低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)可通过刺激动脉平滑肌细胞增殖等机制促进动脉粥样硬化的形成[1-2]。Moorhead等[3]率先提出脂质代谢异常的肾毒性学说,大量临床资料表明肾病综合征、糖尿病及高血压 Oxidative low density lipoprotein (ox-LDL) can promote the formation of atherosclerosis by stimulating the proliferation of arterial smooth muscle cells and other mechanisms [ 2]. Moorhead et al [3] first proposed nephrotoxicity theory of abnormal lipid metabolism, a large number of clinical data show that nephrotic syndrome, diabetes and hypertension