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目的:探讨凋亡相关蛋白Survivin和突变型p53在膀胱移形细胞癌(BTCC)中的表达及其临床意义。方法:应用SP免疫组织化学法检测50例BTCC及10例正常膀胱黏膜组织石蜡切片中Survivin和p53表达的情况,结合临床资料进行分析。结果:Survivin在BTCC的肿瘤标本中的阳性表达率为76%(38/50),而正常对照组中无一例呈阳性表达;Survivin的表达与BTCC的组织学分级、预后显著相关(二者均P<0.05),但与临床病理分期无关(P>0.05);p53在BTCC肿瘤标本中的阳性表达率为68%(34/50),与对照组阳性表达率30%(3/10)相比有统计学意义(P<0.05)。p53的表达与BTCC组织学分级、临床分期及复发相关(均P<0.05);相关性分析表明,BTCC肿瘤组织中Survivin的表达与p53表达呈正相关(r=0.317,P<0.05)。结论:Survivin在BTCC组织中选择性表达,与BTCC的分化程度及复发密切相关;p53蛋白在BTCC中的表达与分级、分期及复发相关,联合评估Survivin和p53蛋白对于判断BTCC预后有重要临床指导意义。
Objective: To investigate the expression of survivin and mutant p53 in bladder transitional cell carcinoma (BTCC) and its clinical significance. Methods: SP immunohistochemistry was used to detect the expression of Survivin and p53 in 50 cases of BTCC and 10 cases of normal bladder mucosa. The clinical data were analyzed. Results: The positive rate of Survivin expression in BTCC was 76% (38/50), but no positive expression was found in Survivin. The expression of Survivin was significantly correlated with the histological grade and prognosis of BTCC (both P <0.05), but not related to the clinical stage (P> 0.05). The positive rate of p53 in BTCC was 68% (34/50), which was significantly higher than that in the control group Than statistically significant (P <0.05). The expression of p53 was correlated with histological grading, clinical stage and recurrence of BTCC (all P <0.05). Correlation analysis showed that there was a positive correlation between the expression of Survivin and p53 in BTCC (r = 0.317, P <0.05). CONCLUSIONS: Survivin is selectively expressed in BTCC tissues, which is closely related to the differentiation and recurrence of BTCC. The expression of p53 protein in BTCC is related to the grade, stage and recurrence of BTCC. Combined evaluation of Survivin and p53 protein has important clinical guidance in judging the prognosis of BTCC significance.