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目的研究普鲁卡因胺抗血栓及其作用机理。方法给小鼠注射胶原和肾上腺素混合液，制造肺血栓模型，用放免法测定６－ｋｅｔｏ－ＰＧＦ１ａ和ＴＸＢ２含量。结果普鲁卡因胺５ｍｇ／ｋｇ，１０ｍｇ／ｋｇ和２０ｍｇ／ｋｇ使小鼠的幸存率增加３３．３％－８０.０％；使６－ｋｅｔｏ－ＰＧＦ１ａ的产量提高７０.８％－２２３.９％；而同时抑制ＴＸＢ_２的产生，抑制率为２０．５％－４４.７％，６－ｋｅｔｏ－ＰＧＦ１ａ与ＴＸＢ_２的比值明显提高，对照组为１.２，药物组为２．６，４.０和７.１。结论普鲁卡因胺具有明显的抗肺血栓作用，其作用与６-ｋｅｔｏ-ＰＧＦ１ａ和ＴＸＢ_２的比值增加有关。
Objective To study the anti-thrombosis of procainamide and its mechanism. Methods Mice were injected with a mixture of collagen and epinephrine to make a pulmonary thrombus model. The contents of 6-keto-PGF1a and TXB2 were determined by radioimmunoassay. RESULTS Prussianamine 5 mg / kg, 10 mg / kg and 20 mg / kg increased the survival rate of mice by 33.3% -80.0%; the yield of 6-keto-PGF1a increased by 70.8% -223. 9%; while inhibiting the production of TXB_2, the inhibition rate was 20.5% -44.7%, the ratio of 6-keto-PGF1a and TXB_2 was significantly increased in the control group was 1.2, the drug group was 2.6,4 .0 and 7.1. Conclusion Prussianamine has a significant anti-pulmonary thrombosis effect, which is related to the increased ratio of 6-keto-PGF1a and TXB2.