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目的观察辛伐他汀与低分子肝素钙联合治疗不稳定型心绞痛的临床疗效。方法将50例不稳定型心绞痛患者随机分为对照组25例,治疗组25例。对照组给予硝酸脂类、β-受体阻滞剂、血管紧张素转换酶抑制剂、阿司匹林等常规治疗,治疗组在上述治疗的基础上给予腹部皮下注射低分子肝素钙0.4ml,每日2次,睡前口服辛伐他汀20mg,连服4周进行疗效比较。结果对照组总有效率为76%,治疗组为96%,两组比较差异有统计学意义(P<0.05)。结论辛伐他汀与低分子肝素钙联合治疗不稳定型心绞痛疗效显著,不良反应少。
Objective To observe the clinical effect of simvastatin combined with low molecular weight heparin calcium in the treatment of unstable angina pectoris. Methods Fifty patients with unstable angina were randomly divided into control group (25 cases) and treatment group (25 cases). The control group was treated with nitrates, β-blockers, angiotensin converting enzyme inhibitors, aspirin and other conventional treatment. The treatment group was given subcutaneous abdominal injection of low molecular weight heparin 0.4ml, 2 Times, before going to bed Simvastatin orally 20mg, even for 4 weeks for efficacy comparison. Results The total effective rate was 76% in the control group and 96% in the treatment group, with significant difference between the two groups (P <0.05). Conclusion Simvastatin and low molecular weight heparin calcium combined with unstable angina pectoris have obvious curative effect and few adverse reactions.