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目的 对生物农药白僵菌原药进行急性经口、经皮、吸入毒性试验 ,眼刺激试验和致敏 (皮肤变态反应 )试验。方法 按照《农药登记毒理学试验方法》(GB1 5 6 70— 1 995 )进行操作。结果 该受试物对雄、雌性大鼠急性经口LD50 >5 0 0 0mg kg ;对雄、雌性大鼠急性经皮LD50 (4h) >2 1 5 0mg kg ;对雄、雌性大鼠急性吸入LC50 (2h) >5 0 0 0mg m3;对实验兔急性眼刺激的平均指数为 0 ;对豚鼠致敏 (皮肤变态反应 )试验 ,致敏率为 1 6 7%。结论 该受试物急性经口属微毒性、急性经皮属低毒性、急性吸入属微毒性 ,眼刺激试验为无刺激性 ,致敏 (皮肤变态反应 )试验属Ⅱ级轻度致敏物
OBJECTIVE To study the acute oral, transdermal, inhalation toxicity test, eye irritation test and sensitization (skin allergy) test of biological pesticide Beauveria. Methods According to the “Pesticide Registration Toxicology Test Method” (GB1 5 6 70- 1 995) to operate. Results The acute oral LD50 of the test substance in male and female rats was> 500 mg kg; acute percutaneous LD50 (4h)> 2150 mg kg in male and female rats; acute inhalation of male and female rats LC50 (2h)> 500 mg / m3. The average index of acute ocular irritation in experimental rabbits was 0. The sensitization rate of skin sensitization to guinea pigs was 16.7%. Conclusion The test substance is acute oral toxicity, acute dermal is low toxicity, acute inhalation is a micro-toxicity, eye irritation test is non-irritating, sensitization (skin allergy) test is a mild allergy Ⅱ