基因传递十分复杂 ,使用简单的载体分子难以完成。模拟病毒的重要性质 ,设计合成多组分载体。有些解决方法 ,如递送细胞锚定分子或正常功能的内源性核输入机制是直接拷贝自细菌和病毒的作用过程 ;另一些方法具有原创性 ,如由去污剂二聚体化进行单分子基因组浓缩 ,或由质子吸附作用引发核内体的破裂 ,这些效应是天然的细胞侵袭者所不具备的。所有这些功能组分有待装配成一种独特的超分子系统 ,即“人工病毒”。 Gene delivery is complex and difficult to accomplish with simple vector molecules. To mimic the important properties of viruses, a multi-component vector was designed and synthesized. Some solutions, such as endogenous nuclear import mechanisms that deliver cellular anchoring molecules or normal functions, are direct copies of the processes that originated from bacteria and viruses; others are original, such as single molecule dimerization by detergent Genome concentration, or proton adsorption caused by the rupture of endosomes, these effects are natural cell invasion do not have. All of these functional components are to be assembled into a unique supramolecular system called “artificial viruses.”