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Hep A腹水肝癌小鼠腹腔注射亲癌荧光染料罗丹明6GDN(Rh 6GDN)2.0mg/kg后,肝癌细胞抑制现象出现缓慢而作用持久。癌细胞呈变性形态学改变。于接种肿瘤后第1、3、5d分别注射生理盐水0.4ml、Rh 6GDH 0.5mg/kg、2-脱氧葡萄糖(2-DG)1.0g/kg、Rh 6GDN 0.5mg/kg加2-DG 1.0g/kg和5-FU10.0mg/kg后,各组肝癌小鼠的平均生存天数分别为14.3、17.7、16.6、20.7(p<0.01)和21.6d(p<0.01)。上述资料表明Rh 6GDN有直接肝癌细胞毒效应,与2-DG合用于Hep A肝癌小鼠有明显疗效。
Hep A ascites liver cancer mice intraperitoneally injected with rhodamine 6GDN (Rh 6GDN) 2.0 mg/kg intraperitoneally, the inhibition of liver cancer cells appeared slowly and lasted for a long time. Cancer cells have degenerative morphological changes. Physiological saline 0.4ml, Rh 6GDH 0.5mg/kg, 2-deoxyglucose (2-DG) 1.0g/kg, Rh 6GDN 0.5mg/kg plus 2-DG 1.0g were injected on the first, third, and fifth days after tumor inoculation. After /kg and 5-FU 10.0mg/kg, the average survival days of liver cancer mice in each group were 14.3, 17.7, 16.6, 20.7 (p<0.01) and 21.6 days (p<0.01). These data indicate that Rh 6GDN has a direct hepatocellular cytotoxicity effect, and has a significant therapeutic effect in combination with 2-DG in Hep A liver cancer mice.