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目的探讨合并动脉粥样硬化(AS)的糖尿病(DM)、高血压患者颈动脉粥样硬化与超敏C反应蛋白(hs-CRP)水平变化的关系。方法 68例住院患者,根据颈动脉内中膜[(颈动脉内膜中层厚度(IMT)≥0.9 mm)]和(或)颈动脉硬化斑块形成,分为颈动脉硬化组(41例)和无颈动脉硬化组(27例)。根据有无合并糖尿病,分为糖尿病合并高血压组(31例)与单纯高血压患者(37例)。采用彩色多普勒超声检查IMT、颈动脉斑块积分、测定血hs-CRP、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、空腹血糖(FBG)等。结果颈动脉硬化组IMT[(1.02±0.32)mm VS(0.73±0.10)mm]、hs-CRP[(4.90±4.05)mg/L VS(2.22±2.50)mg/L]、斑块积分[(3.23±3.01)mm VS(0.00±0.00)mm]值均高于无颈动脉硬化组(P<0.05);糖尿病合并高血压组与单纯高血压组hs-CRP[(5.07±4.46)mg/L VS(2.80±2.65)mg/L]、IMT[(0.94±0.33)mm VS(0.88±0.46)mm]、斑块积分[(2.65±3.23)mm VS(1.20±2.36)mm]值比较,差异无统计学意义(P>0.05)。结论 CRP与2型糖尿病(T2DM)、高血压早期动脉粥样硬化有关。故临床上可将hs-CRP作为反映2型糖尿病、高血压及其大血管病变发生发展的一个重要指标。心血管疾病危险性评估为高危性,建议给予抗炎与抗栓同时治疗。
Objective To investigate the relationship between carotid atherosclerosis and high-sensitivity C-reactive protein (hs-CRP) levels in patients with diabetes mellitus (DM) and hypertension with atherosclerosis (AS). Methods Sixty-eight inpatients were divided into carotid atherosclerosis group (41 cases) and carotid atherosclerosis group according to carotid intima-media thickness (carotid intima-media thickness (IMT) ≥0.9 mm) and / or carotid plaque formation No carotid atherosclerosis group (27 cases). According to the presence or absence of diabetes mellitus, the patients were divided into diabetic hypertension group (n = 31) and simple hypertension patients (n = 37). The IMT, carotid artery plaque score, blood hs-CRP, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein -C), fasting blood glucose (FBG) and the like. Results IMT (1.02 ± 0.32) mm VS (0.73 ± 0.10) mm], hs-CRP [4.90 ± 4.05 mg / L vs 2.22 ± 2.50 mg / L] 3.23 ± 3.01) mm VS (0.00 ± 0.00) mm] were higher than those without carotid atherosclerosis group (P <0.05); The hs-CRP in diabetic hypertensive group and simple hypertensive group [(5.07 ± 4.46) mg / L (2.80 +/- 2.65) mg / L, (2.94 +/- 0.33) mm vs (2.65 +/- 3.23) mm VS (1.20 +/- 2.36) mm] No statistical significance (P> 0.05). Conclusion CRP is associated with type 2 diabetes mellitus (T2DM) and early atherosclerosis of hypertension. Therefore, hs-CRP can be used clinically as an important indicator of the occurrence and development of type 2 diabetes, hypertension and its major vascular diseases. Risk assessment of cardiovascular disease is high risk, it is recommended to give anti-inflammatory and antithrombotic treatment.