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为探讨血管紧张素转换酶(ACE)基因多态分布在不伴肾损害的过敏性紫癜(HSP)与紫癜性肾炎(HSPN)之间的差异性,用PCR方法对50例不伴肾损害的HSP患儿、67例HSPN患儿及100名健康儿童进行ACE基因型分布分析。结果显示:不伴肾损害的HSP患儿ACE各基因型发生频率与正常人无明显差异(P>0.05).而HSPN患儿DD基因型发生频率明显高于不伴肾损害的HSP患儿(P<0.01)。提示具有ACE基因DD型的HSP患儿较易发生HSPN。
To investigate the difference of polymorphism of angiotensin converting enzyme (ACE) gene polymorphisms between HSPN and HSPN without renal damage, PCR was used to detect the polymorphism of ACE gene in 50 patients without renal damage HSP in children, 67 HSPN children and 100 healthy children for ACE genotype distribution analysis. The results showed that there was no significant difference in the frequency of ACE genotypes among children with HSP without renal injury (P> 0.05), while the frequency of DD genotype in children with HSPN was significantly higher than those without HSP P <0.01). It is suggested that HSPNs with ACE gene DD type are more likely to develop HSPN.