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目的分析急性心肌梗死患者不同梗死部位血B型钠尿肽(BNP)水平和心功能的变化关系。方法选择AMI住院患者62例和对照组47例,于入院后24h内采用酶联免疫法(ELISA)测定血浆BNP浓度,入院后1周行心脏彩超检查,计算左室射血分数(LVEF),观察AMI患者不同梗死部位血浆BNP水平的变化和LVEF的变化。结果 AMI组患者血浆BNP水平较对照组显著升高,而且前壁组血浆BNP水平升高较下壁组更明显;AMI组患者LVEF较对照组明显下降,前壁组LVEF下降较下壁组更明显。结论 AMI患者不同梗死部位血浆BNP水平具有明显差异,血浆BNP升高越明显的梗死部位LVEF下降越明显。
Objective To analyze the relationship between blood B-type natriuretic peptide (BNP) levels and cardiac function in patients with acute myocardial infarction. Methods Sixty-two inpatients with AMI and 47 in control group were enrolled in this study. BNP concentration was measured by enzyme-linked immunosorbent assay (ELISA) within 24h after admission. Cardiac color Doppler ultrasound examination was performed one week after admission to calculate left ventricular ejection fraction (LVEF) The changes of plasma BNP level and LVEF in different infarction sites of AMI patients were observed. Results The level of plasma BNP in patients with AMI was significantly higher than that in control group, and the plasma BNP level in anterior wall group was more obvious than that in lower wall group. The LVEF in AMI group was significantly lower than that in control group, while the LVEF in anterior wall group was lower than that in lower wall group obvious. Conclusion There is a significant difference in plasma BNP levels in different infarction sites in patients with AMI. The more obvious elevation of BNP is, the more obvious the decrease of LVEF is.