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甲苯二异氰酸酯具有毒作用,并可引起过敏反应。接触甲苯二异氰酸酯可产生急性、亚急性和慢性中毒。甲苯二异氰酸酯中毒最常见的表现之一为肝功能障碍。作者通过250名接触甲苯二异氰酸酯工人的门诊检查,发现16%有肝肿大现象。接着进一步对33名门诊检查发现有肝功能异常或确诊为中毒性肝炎的病例,收容住院进行了深入的临床和实验室检查。结果如下: (一)临床检查主诉右季肋部疼痛(18例)、恶心(5例)、胃灼热感(3例)。肝脏轻度或中等度增大(20例),均属质软、表面光滑、边缘锐利。肝脏触瘸(12例)。
Toluene diisocyanate has a toxic effect and can cause an allergic reaction. Exposure to toluene diisocyanate can cause acute, subacute and chronic poisoning. One of the most common manifestations of toluene diisocyanate poisoning is liver dysfunction. The author examined 250 outpatients exposed to toluene diisocyanate and found that 16% had hepatomegaly. Then further 33 cases of outpatient examination found abnormal liver function or diagnosed with toxic hepatitis, admitted to hospital for in-depth clinical and laboratory tests. The results are as follows: (a) clinical examination complained of right quarter rib pain (n = 18), nausea (n = 5), heartburn (n = 3). Liver mild or moderate increase (20 cases), are soft, smooth surface, sharp edges. Liver contact lame (12 cases).