论文部分内容阅读
目的：探讨多次肝动脉化疗栓塞术（ＴＡＣＥ）对肝纤维化进程的影响。材料与方法；选择２４例经三次以上ＴＡＣＥ治疗的肝癌患者，测定每次ＴＡＣＥ治疗前后透明质酸（ＨＡ）、人Ⅲ型前胶原（ｈｐｃⅢ）和Ⅳ型胶原（Ⅳ·Ｃ）的血清学水平，并进行比较研究。结果：ＴＡＣＥ治疗前后对比，三次肝纤维化指标均有不同程度的升高，以第三次ＴＡＣＥ术后升高最明显（Ｐ＜０．０１），三项肝纤维化指标中，以Ⅳ·Ｃ变化最显著，第一次ＴＡＣＥ术后即有统计学意义（Ｐ＜０．０５）。结论： ＴＡＣＥ治疗加重了肝纤维化进展，值得我们注意。
Objective: To investigate the effect of multiple hepatic arterial chemoembolization (TACE) on the progression of hepatic fibrosis. Materials and Methods; 24 HCC patients who were treated with TACE more than three times were selected to determine the serological level of hyaluronic acid (HA), human type III procollagen (hpcIII) and type IV collagen (IV·C) before and after each TACE treatment. And conduct comparative studies. RESULTS: Before and after TACE treatment, the indexes of hepatic fibrosis were increased in different degrees, and the increase was most obvious after the third TACE (P<0.01). Among the three indicators of hepatic fibrosis, IV· The most significant change was in C, which was statistically significant after the first TACE (P<0.05). Conclusion: TACE treatment aggravates the progression of liver fibrosis and deserves our attention.