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由于自身抗体对壁细胞的破坏,恶性贫血(简称PA)常伴有胃酸缺乏和高胃泌素血症.已经证实PA时胃窦部G/D细胞比例增加.本研究旨在测定临床诊断为PA并由组织学证实的A型慢性萎缩性胃炎患者血浆生长抑素水平和胃窦及胃体粘膜中胃泌素、生长抑素量以及嗜银细胞数.病例和方法:PA5例中女性3例,男性2例,62～69岁,平均65.6岁.均为维生素B_(12)缺乏性巨幼红细胞性贫血,5肽胃泌素试验证实胃酸缺乏.对照组为6例无溃疡的消化不良,女性4例,男性2例,内窥镜检查均无食管、胃、十二指肠病变,活检无萎缩性改变.两组病人均在胃大弯和胃窦小弯侧取活检.活检取材包括粘膜和粘膜肌层.每个部位至少取3块标本,用以测定
Due to the destruction of parietal cells by autoantibodies, pernicious anemia (abbreviated as PA) is often accompanied by gastric acid deficiency and hypergastrinemia. The proportion of G/D cells in gastric antrum has been confirmed to increase in PA. The purpose of this study was to determine the clinical diagnosis. PA and histologically confirmed plasma somatostatin levels in patients with chronic atrophic gastritis A and gastrin, somatostatin, and argyrophil counts in the antrum and gastric mucosa. Cases and methods: PA 5 females 3 Cases, 2 males, 62 to 69 years old, average 65.6 years old. All of them were vitamin B_(12)-deficient megaloblastic anemia. Gastric acid deficiency was confirmed by 5-gastrin gastrin test. The control group had 6 indigestion without ulcers. There were 4 females and 2 males. There were no esophageal, gastric and duodenal lesions in endoscopy. There was no atrophic change in biopsy. Both groups of patients underwent biopsy in the major curvature of the stomach and small antrum curvature. Including mucous membranes and muscularis mucosa. Take at least 3 specimens from each site for measurement