论文部分内容阅读
目的了解河北省健康人群肾综合征出血热病毒(HV)隐性感染情况,观察肾综合征出血热双价灭活疫苗的免疫效果。方法选择河北省滦南、北戴河、昌黎3个县为疫苗接种点,接种对象为16~60岁的健康人群(去除HFRS既往感染者及疫苗禁忌症者),用荧光抗体病毒中和试验(FAVN)的方法测定免疫前、免疫后中和抗体。结果疫苗免疫前人群血清HV中和抗体阳性率为2.92%,免疫后人群血清HV中和抗体阳性率(70.42%)比免疫前显著升高(P<0.05);免疫前HV中和抗体阳性率在各年龄段之间差异无统计学意义(P>0.05),免疫后各年龄组之间差异有统计学意义(P<0.05),且各年龄段及总人群免疫后抗体阳性率均显著高于免疫前(P<0.001);疫苗免疫后抗体滴度升高,各年龄组间抗体滴度差异无统计学意义(P>0.05)。结论肾综合征出血热双价灭活疫苗免疫效果显著,值得推广。
Objective To understand the latent infection of hemorrhagic fever with renal syndrome virus (HV) in healthy population in Hebei Province and to observe the immune effect of bivalent inactivated vaccine against hemorrhagic fever with renal syndrome. Methods Three counties in Luannan, Beidaihe and Changli of Hebei Province were selected as vaccine inoculation sites. The vaccinated groups were healthy population aged from 16 to 60 years (those with previous HFRS infection and contraindications to vaccine). Fluorescent antibody neutralization test (FAVN ) Method for the determination of pre-immune and post-immunization neutralizing antibodies. Results The positive rate of serum HV neutralizing antibody before immunization was 2.92%, and the positive rate of serum HV neutralizing antibody (70.42%) after immunization was significantly higher than that before immunization (P <0.05). The positive rate of HV neutralizing antibody before immunization There was no significant difference among all age groups (P> 0.05). There was a significant difference between all age groups after immunization (P <0.05), and the positive rate of antibody in all age groups and the total population was significantly higher Before immunization (P <0.001), the antibody titer increased after vaccination, and the antibody titers of all age groups had no significant difference (P> 0.05). Conclusion The dual immunization inactivated vaccine of hemorrhagic fever with renal syndrome has significant immunization effect and is worth promoting.