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MicroRNA是一类进化上高度保守的单链小分子RNA,参与调控机体生长、发育、代谢以及疾病的发生.最近研究表明,一部分MicroRNA在过敏性炎症特别是支气管哮喘的发病过程中起重要作用.研究microRNA-21在哮喘发病中的调节机制,可帮助寻找安全、高效、特异的治疗方法.该文就miR-NA-21与支气管哮喘发病机制相关作用予以综述.“,”MicroRNAs are a class of small,single-stranded,highly conserved RNAs,which contributes to the regulation of growth,development,metabolism and disease.Recent studies have shown that a few microRNAs play a vital role in allergic inflammation with special focus on bronchial asthma.To investigate the regulation mechanism of microRNA-21 in the pathogenesis of asthma can help to find a safe,effective and specific therapy.In this paper,the role of miRNA-21 in the pathogenesis of asthma is reviewed.