正己烷及其代谢物的神经毒性作用,已被人和动物实验所证实,但其对免疫功能的作用尚未见报道。因此,作者用正己烷代谢物中毒性最强的2,5-己二醇,研究它对小鼠免疫能力的影响。实验选用Swiss Albino小鼠。实验前,首先测定小鼠急性口服2,5-己二醇半数致死量(LD_(50))。然后给实验组小鼠一次灌胃1/5 LD_(50)剂量2,5己-二醇,于投给后第7天处死部分 The neurotoxic effects of n-hexane and its metabolites have been demonstrated in human and animal experiments, but their effects on immune function have not been reported. Therefore, the authors used 2,5-hexanediol, the most toxic metabolite of n-hexane, to investigate its effect on the immunocompetence of mice. The experiment selected Swiss Albino mice. Before the experiment, the mice were first tested for half-lethal dose of 2,5-hexanediol (LD_ (50)). The mice in the experimental group were then given a dose of 1/5 LD_ (50) of 2,5-diol at a time, and sacrificed on the 7th day