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目的采用血清杀菌力试验,监测辽宁省不同年龄组健康人群血清C群脑膜炎奈瑟菌(Neisseria Meningitidis,Nm)杀菌力水平,以评价健康人群对C群Nm的抗体保护水平。方法随机抽取8个年龄组共240份健康人群血清样品,试验菌株为C群Nm疫苗株(C11)和目前我国C群Nm流行株(053442)。结果240份健康人群血清中,48.33%C群Nm抗体阳性(抗体滴度≥1:2)。对疫苗菌株C11的总保护率(抗体滴度≥1:8)为35.83%,其中≤6岁仅为13.33%,7～19岁61.67%,20～39岁46.67%,≥40岁63.33%。≥15岁健康人群血清对C群流行菌株(053442)的杀菌力低于对C11疫苗株,差异有统计学意义。结论辽宁省≤6岁健康人群对C群Nm血清杀菌力水平较低,实施扩大免疫规划后,≤3岁儿童仍需采取措施提高C群Nm抗体水平。
Objective To detect the bactericidal level of Serum C group Neisseria Meningitidis (Nm) in healthy population of different age groups in Liaoning Province by using the bactericidal test of serum in order to evaluate the antibody protection level of C group Nm in healthy population. Methods Serum samples of 240 healthy people from 8 age groups were randomly selected. The test strains were C group Nm vaccine strain (C11) and C strain Nm epidemic strain (053442). Results Serum of 240 healthy people were positive for 48.33% C group Nm antibody (antibody titer≥1: 2). The total protection rate (antibody titer≥1: 8) to vaccine strain C11 was 35.83%, of which 13.33% were ≤6 years old, 61.67% were from 7 to 19 years old, 46.67% were from 20 to 39 years old, and 63.33% were from 40 years old. The serum of 15-year-old healthy people had lower bactericidal efficacy against the C-strain (053442) than that of the C11 vaccine strain. The difference was statistically significant. Conclusion The level of Nm serogroup C bactericidal activity in healthy population of ≤6 years in Liaoning Province is low. After the immunization program is expanded, children ≤3 years old still need to take measures to raise the level of Nm antibody of C group.