健康早产儿和足月儿出生时的凝血系统都未成熟,出生后逐渐达到成人的水平。健康新生儿血浆促凝和抑制物的浓度与成人不同,使新生儿凝血酶生成减少,凝血酶抑制功能受损。但新生儿血浆促凝与抑制物仍处于生理平衡。呼吸窘迫综合征(RDS)患儿易发生出血和血栓形成并发症与其血浆促凝和抑制物明显低于健康新生儿有关。改变的血浆促凝和抗凝物浓 Healthy premature babies and full-term infants born at the age of the clotting system are immature, and gradually reached the adult level after birth. The concentration of plasma procoagulants and inhibitors in healthy newborns is different from that in adults, resulting in reduced thrombin generation and impaired thrombin inhibition in neonates. However, neonatal plasma procoagulant and inhibitors are still in a physiological balance. Bleeding and thrombotic complications in children with respiratory distress syndrome (RDS) are associated with significantly lower plasma levels of procoagulant and antihypertensive agents than healthy newborns. Altered plasma procoagulant and anticoagulant concentrations