阿斯匹林是使用最为广泛的解热镇痛药。近年来,对阿斯匹林与其他药物的相互作用曾作了大量研究。现将有关报道简述如下: 1.肝素:因阿斯匹林可降低血小板的粘性,故应用肝素者应避免并用阿斯匹林。 2.氨甲喋呤:阿斯匹林与氨甲喋呤联用,可增加或延缓血桨游离氯甲喋呤的浓度,从而使毒性增加。这种机制是由于阿斯匹林可置换氨甲喋呤的血桨蛋白结合部位,或竞争了氨甲喋呤的肾排泄所致。据报道,当两种药物并用时,氨甲喋呤的肾清除率可 Aspirin is the most widely used antipyretic and analgesic. In recent years, a great deal of research has been conducted on the interaction of aspirin with other drugs. Now report briefly as follows: 1. Heparin: Because aspirin can reduce platelet viscosity, so the application of heparin should be avoided and used aspirin. 2. Methotrexate: Aspirin and methotrexate in combination, can increase or delay the concentration of plasma free methotrexate, resulting in increased toxicity. This mechanism is due to the fact that aspirin displaces the plasma protein binding site of methotrexate, or competes for renal excretion of methotrexate. It has been reported that when both drugs are used, the renal clearance of methotrexate can be