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目的探讨精子形态与精子顶体酶活性的关系。方法对395例男性不育患者采用精子形态检测系统下人工修正方法分析精子形态,用酶标法检测精子中的顶体酶和顶体酶活力指数(AAI)。结果精子形态正常组的顶体酶活性明显高于精子形态异常组,两组差异显著(P<0.05);顶体酶活性正常组形态正常精子百分率明显高于顶体酶活性异常组形态正常精子百分率,两组间较差异极显著(P<0.001);顶体酶活性与形态正常精子百分率间呈显著正相关关系(r=0.169,P<0.001)。结论精子形态可影响精子顶体酶活性。
Objective To explore the relationship between sperm morphology and sperm acrosin activity. Methods 395 male infertility patients were tested for sperm morphology by sperm morphology correction system and sperm enzyme and acrosin activity index (AAI) by enzyme-linked immunosorbent assay (ELISA). Results The acrosin activity of the sperm normal group was significantly higher than that of the sperm morphology abnormal group (P <0.05). The percentage of sperm with normal acrosin activity was significantly higher than that of the normal acrosin group (P <0.001). There was a significant positive correlation between acrosin activity and percentage of morphologically normal spermatozoa (r = 0.169, P <0.001). Conclusion Sperm morphology can affect sperm acrosin activity.