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本文报道人参总皂甙对花生四烯酸在免血小板中代谢的影响。方法采用放射薄层扫描、放射自显影及放射活性测定等同位素技术。结果表明,人参总皂甙抑制兔血小板血栓素A_2的生物合成,并呈量效关系。同时对前列腺素A_2也有抑制作用。这种抑制怍用的机理,可能是人参总皂甙抑制了血小板环氧酶和血栓素A_2合成酶的活性。
This article reports the effects of ginsenosides on the metabolism of arachidonic acid in platelets. Methods Radioisotope scanning, autoradiography and radioactive isotope techniques were used. The results showed that ginseng saponin inhibited rabbit thromboxane A_2 biosynthesis, and the dose-response relationship. At the same time on prostaglandin A_2 also inhibitory effect. The mechanism of this inhibition may be that ginseng saponin inhibits the activity of platelet cyclooxygenase and thromboxane A 2 synthase.