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目的 探讨重型病毒肝炎患者血清胆碱脂酶动态变化规律及其与预后的关系。方法 定期检测重 型肝炎和有重型肝炎倾向者血清的胆碱脂酶水平,同步检测肝功能指标。根据病情转归将重型肝炎分为好转组和 死亡组。对检测结果作数理分析及统计学处理。结果 重型病毒性肝炎患者血清胆碱脂酶(PChE)水平显著降低 (P<0.01),且呈现胆红素(SB) 血清胆碱脂酶(PChE)分离现象。其中,好转组与死亡组相比较,PChE、SB/PChE 之差别有高度统计学意义(P<0.01)。结论 重型病毒性肝炎患者PChE活性、SB与PchE分离程度可作为重型 肝炎严重程度的有效指标,对病情诊断及判断预后有重要指导意义。
Objective To investigate the dynamic changes of serum cholinesterase in patients with severe viral hepatitis and its relationship with prognosis. Methods Serum levels of cholinesterase in patients with severe hepatitis and severe hepatitis were measured regularly, and liver function indexes were detected simultaneously. According to the prognosis of severe hepatitis were divided into improvement group and death group. The test results for mathematical analysis and statistical processing. Results Serum cholinesterase (PChE) levels were significantly decreased in patients with severe viral hepatitis (P <0.01), and serum cholinesterase (PChE) was observed in patients with severe viral hepatitis. Among them, the difference of PChE and SB / PChE between the improved group and the death group was highly statistically significant (P <0.01). Conclusions PChE activity, the degree of separation of SB and PchE in patients with severe viral hepatitis can be used as an effective indicator of the severity of severe hepatitis, which is of important guiding significance for the diagnosis of the disease and prognosis.