论文部分内容阅读
Objective:To study the effect of Jinguo Weikang Capsule(金果胃康胶囊,JWC)on the gene expression of H-ras,epidermal growth factor receptor(EGFR),P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions,and to investigate the action mechanism of JWC on gastric precancerous lesions.Methods:A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using ~(60)Co irradiation.Rats were divided into the normal group,model group,high-, medium-,low-dose JWC treatment groups,and the vitacoenzyme control group,and were treated for 30 days.The expression of H-ras,EGFR,P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods.Results:The expression and over-expression rates of H-ras,EGFR,P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower(P<0.05) as compared with those of the model group.Conclusion:JWC can inhibit the expression of the H-ras, EGFR,P53 and C-myc genes expression of the gastric mucosa in rats,which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.
Objective: To study the effect of Jinguo Weikang Capsule (JWC) on the gene expression of H-ras, epidermal growth factor receptor (EGFR), P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions, and to investigate the action mechanism of JWC on gastric precancerous lesions. Methods: A rat model with paratypical proliferation of the gastric epithelium mucosa was established by ~ (60) Co irradiation. Rats were divided into the normal group, model group, high, medium-, low-dose JWC treatment groups, and the viticoenzyme control group, and were treated for 30 days. The expression of H-ras, EGFR, P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical Methods. Results: The expression and over-expression rates of H-ras, EGFR, P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P <0.05) group.Conclusion: JWC can inhibit the expression of the H-ras, EGFR, P53 and C-myc g enes expression of the gastric mucosa in rats, which may be one of mechanisms of involved in suppressing or reversing gastric carcinogenesis.