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目的探讨低分子肝素对脑梗死后炎症反应的干预作用。方法应用ELISA方法测定低分子肝素组和葛根素组患者治疗前后TNF蛳α、IL蛳6、IL蛳16、sVCAM蛳1和D蛳Dimer水平。结果低分子肝素组、葛根素组患者TNF蛳α、IL蛳6、IL蛳16、sVCAM蛳1和D蛳Dimer含量明显高于正常对照组,低分子肝素组患者上述指标在治疗后明显下降,于治疗前比较有显著性差异(P<0.01)。结论炎症细胞因子确实参与了急性缺血后的炎症反应,低分子肝素能够抑制细胞因子的表达,可能成为预防急性缺血性梗死后早期病情恶化的有前途的治疗手段。
Objective To investigate the effect of low molecular weight heparin on the inflammatory response after cerebral infarction. Methods The levels of TNF 蛳 α, IL 蛳 6, IL 蛳 16, sVCAM 蛳 1 and D 蛳 Dimer in low molecular weight heparin group and puerarin group before and after treatment were measured by ELISA. Results The levels of TNF 蛳 α, IL 蛳 6, IL 蛳 16, sVCAM 蛳 1 and D 蛳 Dimer in the low molecular weight heparin group and the puerarin group were significantly higher than those in the normal control group. The above indexes in the low molecular weight heparin group were significantly decreased after treatment, Before treatment, there was a significant difference (P <0.01). Conclusion Inflammatory cytokines are indeed involved in the inflammatory response after acute ischemia. Low molecular weight heparin can inhibit the expression of cytokines and may be a promising therapeutic approach to prevent the early deterioration of acute ischemic infarction.