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目的:观察中药复方对肺癌化疗患者临床并发症改善效果,探讨改善机理。方法:对本院自2010年12月—2013年3月收治肺癌化疗患者进行研究,依据治疗方法分为治疗组(61例)和对照组(42例),治疗组在化疗的同时给予中药复方治疗,对照组单纯进行化疗治疗。观察患者TNF-α、IL-2、IL-4和IL-10水平变化,比较临床并发症发生率。结果:治疗组患者血清TNF-α和IL-2水平较对照组有所升高,而血清IL-4和IL-10水平有所降低,患者并发症状发生率较低,两组比较,差异有统计学意义(P<0.05)。结论:中药复方能够提升患者血清TNF-a和IL-2水平,降低IL-4和IL-10水平,调节患者Th1/Th2平衡;改善患者因化疗出现的并发症状,临床疗效甚佳。
Objective: To observe the improvement effect of traditional Chinese medicine compound on clinical complications of patients with lung cancer chemotherapy and to explore the mechanism of improvement. Methods: The patients with lung cancer who underwent chemotherapy in our hospital from December 2010 to March 2013 were divided into treatment group (61 cases) and control group (42 cases). The treatment group was treated with chemotherapy Treatment, control group chemotherapy alone. The changes of TNF-α, IL-2, IL-4 and IL-10 in patients were observed, and the incidence of clinical complications was compared. Results: Serum levels of TNF-α and IL-2 in the treatment group were significantly higher than those in the control group, while the levels of serum IL-4 and IL-10 were decreased and the incidence of complications was lower in the two groups Statistical significance (P <0.05). Conclusion: The Chinese herbal compound can improve the levels of serum TNF-a and IL-2, reduce the levels of IL-4 and IL-10, regulate the balance of Th1 / Th2 in patients, and improve the patients’ clinical curative effect due to the complications of chemotherapy.