目的:探讨血清骨保护素(OPG)水平与冠状动脉钙化(Coronary artery calcification,CAC)的相关性。方法:入选50例患者,所有入选患者均冠状动脉16层螺旋CT扫描,根据结果,CAC的患者30例作为实验组,冠脉无钙化者20例作为对照组,在入院24小时内记录各组患者的一般资料(包括性别、年龄、血脂、血糖、血压等),ELISA法检测各组患者血清OPG水平,计算CAC的积分,分析OPG与CAC的相关性。结果:(1)与对照组相比,CAC患者血清OPG均高于对照组,差异有统计学意义(P<0.01);(2)OPG水平与CAC的程度相关,且随着钙化积分的升高而升高,差异有统计学意义(P<0.01);(3)OPG与FPG及LDL水平正相关(P<0.01或P<0.05)。结论:血清OPG浓度与CAC程度密切相关,随着CAC的积分升高而升高,可能参与了CAC的发展,OPG水平与FPG、LDL水平正相关,提示其参与CAC的发展可能与血糖、血脂代谢有关,共同参与了CAC的发展。 Objective: To investigate the relationship between serum osteoprotegerin (OPG) level and coronary artery calcification (CAC). Methods: Fifty patients were enrolled. All patients were scanned by 16-slice spiral CT coronary angiography. According to the results, 30 patients with CAC as experimental group and 20 patients with non-calcified coronary artery as control group. All patients were recorded within 24 hours after admission The general data of patients (including gender, age, blood lipids, blood glucose, blood pressure, etc.), serum OPG levels were measured by ELISA, the CAC score was calculated, and the correlation between OPG and CAC was analyzed. Results: (1) Compared with the control group, serum OPG levels in CAC patients were significantly higher than those in the control group (P <0.01); (2) OPG levels were correlated with the degree of CAC, (P <0.01). (3) There was a positive correlation between OPG and FPG and LDL (P <0.01 or P <0.05). CONCLUSIONS: Serum OPG concentration is closely related to the degree of CAC, and increases with the increase of CAC. It may be involved in the development of CAC. OPG level is positively correlated with FPG and LDL levels, suggesting that the involvement of CAC may be related to blood glucose, Metabolism, and participate in the development of CAC.