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目的探讨肥胖致前列腺癌的因果关系,为前列腺癌的预防和病因研究提供参考依据。方法分别用“肥胖”、“前列腺癌”、“Meta分析”中的英文检索词检索中国期刊网、Science Direct、Springer Link、等数据库,检索近10年公开发表的有关肥胖与前列腺癌的研究文献,分别采用RevMan 5.0软件中的分类数据和一般反向方差法进行Meta分析。结果纳入该次分析的文献共有6篇,累计病例3 328例,对照535 724例。单项研究的OR值范围为0.78～1.31,合并OR值为1.11,95%可信区间为1.01～1.23。结论病例对照文献提示前列腺癌与肥胖存在联系。
Objective To investigate the causal relationship between obesity and prostate cancer, and to provide a reference for the prevention and etiology of prostate cancer. Methods The databases of Chinese Journal Net, Science Direct, Springer Link and other databases were searched by using the English terms in “Fat”, “Prostate Cancer” and “Meta Analysis” And prostate cancer research literature, respectively, using RevMan 5.0 software classification data and general inverse variance Meta-analysis. Results A total of 6 articles were included in the analysis, with a total of 3 328 cases and 537 224 cases. The odds ratios (ORs) for individual studies ranged from 0.78 to 1.31 with a combined OR of 1.11 and 95% confidence intervals from 1.01 to 1.23. Conclusions Case-control literature suggests that prostate cancer is associated with obesity.