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目的:探讨肾移植术后巨细胞病毒(cytomegalovirus,CMV)肺炎的有效治疗措施。方法:回顾性分析54例同种异体肾移植术后发生CMV肺炎患者的临床资料,总结肾移植术后CMV肺炎的治疗经验。结果:给予患者积极的抗病毒治疗、适当减少免疫抑制药、预防和治疗二重感染、全身支持疗法、及时采用呼吸机辅助通气等综合治疗措施,54例病人中治愈36例(66.67%),好转6例,死亡8例,4例因脑水肿导致长期昏迷而放弃进一步治疗。结论:CMV肺炎是肾移植术后CMV全身感染的重症之一,确诊后应采取以抗病毒为主的综合治疗措施。
Objective: To investigate the effective treatment of cytomegalovirus (CMV) pneumonia after renal transplantation. Methods: The clinical data of 54 patients with CMV pneumonia after renal allograft transplantation were retrospectively analyzed. The treatment experience of CMV pneumonia after renal transplantation was summarized. Results: The patients were treated with active antiviral therapy, immunosuppressive drugs were appropriately reduced, prophylaxis and treatment of dual infection, general supportive therapy and timely ventilator-assisted ventilation were used. Among 54 patients, 36 cases were cured (66.67%), 6 cases improved, 8 died, 4 cases of cerebral edema lead to long-term coma and give up further treatment. Conclusion: CMV pneumonia is one of the most serious systemic infections of CMV after renal transplantation. After the diagnosis, CMV pneumonia should be taken as an integrated anti-virus therapy.