盐酸二甲双胍自面世以来,其独特的降糖功效受到了广大药物研究者和医务工作者的高度关注,成为药物开发和应用的热点,并迅速在糖尿病的治疗中得到了广泛应用。盐酸二甲双胍的合成方法单一,制剂的剂型制备较简单,本文中略加介绍。重点详述了盐酸二甲双胍在试验研究、临床单独治疗和联合用药应用于糖尿病的治疗方法,以及对糖尿病及其并发症等的临床治疗验证。结果表明,盐酸二甲双胍在糖尿病及其并发症、多囊卵巢综合征等的治疗中疗效显著,副作用很小,值得临床应用推广。 Metformin Hydrochloride since its launch, its unique hypoglycemic effect by the majority of drug researchers and medical workers are highly concerned about the development and application of drugs as a hot spot, and rapidly in the treatment of diabetes has been widely used. The synthesis of metformin hydrochloride is simple, preparation of formulations is relatively simple, in this article a little introduction. It focuses on the methotrexate hydrochloride in experimental research, clinical monotherapy and combination therapy for the treatment of diabetes, as well as the clinical treatment of diabetes and its complications such as validation. The results showed that metformin hydrochloride in the treatment of diabetes mellitus and complications, polycystic ovary syndrome, such as significant effect, side effects are small, worthy of promotion of clinical application.