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目的:观察益气养阴软坚化痰方对实验性动脉粥样硬化(AS)鹌鹑血脂及形态学影响。方法:通过高脂饲料建立鹌鹑AS模型,随机分为5组,正常对照组给予普通饲料,高脂对照组给予高脂饲料,维生素E组给予高脂饲料加维生素E,中药高剂量组给予高脂饲料加益气养阴软坚化痰方,中药低剂量组给予高脂饲料加益气活血化痰方,灌胃给药8周后观察其CH、TG、HDL-C及动脉形态学的变化。结果:维生素E组和中药高剂量组CH、TG值较高脂对照组明显降低(P<0.01),HDL-C值明显升高,且动脉病变较轻,无明显管腔斑块。结论:益气养阴软坚化痰方可以明显降低AS鹌鹑的CH和TG,升高HDL-C,并可降低动脉粥样硬化斑块的发生率。
Objective: To observe the effect of Yiqi Yangyin Ruanjian Huayu Recipe on blood lipid and morphology of experimental atherosclerosis (AS). METHODS: The 鹌鹑AS model was established by high-fat diet and randomly divided into 5 groups. The normal control group was given normal feed, the high-fat control group was given high-fat diet, the vitamin E group was given high-fat diet plus vitamin E, and the high-dose group was given high Lipid feed plus Yiqi Yangyin Ruanjian Huayu Decoction, low-dose Chinese medicine group was given high-fat diet plus Yiqi Huoxue Huayu Decoction, and the changes of CH, TG, HDL-C and arterial morphology were observed after intragastric administration for 8 weeks. . Results: The CH and TG values in the vitamin E group and the high-dose Chinese traditional medicine group were significantly lower (P<0.01), the HDL-C values were significantly higher, and the arterial lesions were lighter. There was no obvious plaque in the lumen. Conclusion: Yiqi Yangyin Ruanjian Huayu Decoction can significantly reduce CH and TG in AS patients, increase HDL-C, and reduce the incidence of atherosclerotic plaque.