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目的探讨中老年男性勃起功能(EF)与血清总睾酮(TT)、游离睾酮(FT)和生物活性睾酮(Bio-T)之间的相关关系。方法采用问卷调查的方式,比较236例正常勃起人群,369例轻度勃起功能障碍(ED)和390例中、重度ED患者的勃起功能指数评分(IIEF),化学发光法(CLIA)检测TT和性激素结合球蛋白(SHBG),计算FT和Bio-T水平。结果中老年男性人群的ED发病率为76.28%,随着增龄而显著升高。ED患者的TT水平略低于正常勃起人群,但差异无统计学意义(P>0.05);而FT和Bio-T显著低于正常勃起人群,差异具有统计学意义(P<0.01)。TT在不同IIEF评分的ED患者之间没有变化规律,FT和Bio-T则随着IIEF评分的减低而明显下降。Pearson相关分析显示:TT与IIEF评分之间无相关性,FT和Bio-T与IIEF评分呈显著正相关(P<0.01)。结论中老年男性ED发病率随增龄显著升高。TT水平与ED无明显相关关系,而FT和Bio-T与ED显著相关;FT和Bio-T内分泌诊断价值优于TT,更能准确反应ED患者的血清睾酮水平。
Objective To explore the correlation between erectile function (EF) and total testosterone (TT), free testosterone (FT) and bioactive T testosterone (Bio-T) in middle-aged and elderly men. Methods The erectile function index (IIEF), 236 erectile dysfunction (ED), 390 erectile dysfunction (ED) and 390 moderate to severe ED patients were compared by questionnaire. Sex hormone binding globulin (SHBG) was calculated for FT and Bio-T levels. Results The incidence of ED in middle-aged and elderly men was 76.28%, which increased significantly with age. The TT level of ED patients was slightly lower than that of normal erection patients, but the difference was not statistically significant (P> 0.05). FT and Bio-T were significantly lower than those of normal erection patients (P <0.01). There was no change in TT between ED patients with different IIEF scores, while FT and Bio-T decreased significantly with the decrease of IIEF score. Pearson correlation analysis showed no correlation between TT and IIEF scores, and there was a significant positive correlation between FT and Bio-T and IIEF scores (P <0.01). Conclusion The incidence of ED in middle-aged and elderly men increased significantly with age. TT levels and ED no significant correlation between the FT and Bio-T and ED was significantly correlated; FT and Bio-T endocrine diagnostic value is better than TT, more accurately reflect the level of serum testosterone ED patients.